The Buffalo Bills are a professional American football team based in the Buffalo metropolitan area. The Bills compete in the National Football League (NFL) as a member club of the league's American Football Conference (AFC) East division. The team plays its home games at Highmark Stadium in Orchard Park, New York. Founded in 1960 as a charter member of the American Football League (AFL), they joined the NFL in 1970 following the AFL–NFL merger. The Bills' name is derived from an All-America Football Conference (AAFC) franchise from Buffalo that was in turn named after western frontiersman Buffalo Bill. Drawing much of its fanbase from Western New York, the Bills are the only NFL team that plays home games in that state. The franchise is owned by Terry and Kim Pegula, who purchased the Bills after the death of original owner Ralph Wilson in 2014.

The Bills won consecutive AFL Championships in 1964 and 1965, the only major professional sports championships from a team representing Buffalo. After joining the NFL, they struggled heavily during the 1970s before they became perennial postseason contenders during the late 1980s to the late 1990s. Their greatest success occurred between 1990 and 1993 when they appeared in a record four consecutive Super Bowls; an accomplishment often overshadowed by them losing each game. From the early 2000s to the mid-2010s, the Bills endured the longest playoff drought of 17 years in the four major North American professional sports, making them the last franchise in the four leagues to qualify for the postseason in the 21st century. They returned to consistent postseason contention by the late 2010s, although the Bills have not returned to the Super Bowl. Alongside the Minnesota Vikings, their four Super Bowl appearances are the most among NFL franchises that have not won the Super Bowl..